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Review
. 1998 Mar;23(3):349-59.
doi: 10.1023/a:1022457500700.

Cytokine-induced inflammation in the central nervous system revisited

J A Martiney  1 , C Cuff, M Litwak, J Berman, C F Brosnan
Affiliations
Review

Cytokine-induced inflammation in the central nervous system revisited

J A Martiney et al. Neurochem Res. 1998 Mar.

Abstract

Cytokines play an essential role as mediators of the immune response. They usually function as part of a network of interactive signals that either activate, enhance, or inhibit the ensuing reaction. An important contribution of this cytokine cascade is the induction of an inflammatory response that recruits and activates subsets of leukocytes that function as effector cells in the response to the sensitizing antigen. Proinflammatory cytokines activate endothelial cells (EC) to express adhesion molecules and induce the release of members of the chemokine family, thus focusing and directing the inflammatory response to sites of antigen recognition. However, the vasculature of the central nervous system (CNS) is highly specialized and restricts the access of components of the immune system to the CNS compartment. In this review, we address the question as to whether endothelial cells in the CNS respond differently to specific cytokines known to induce either a proinflammatory effect or a regulatory effect in systemic vascular beds.

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References

    1. Int J Dev Neurosci. 1995 Jun-Jul;13(3-4):153-65 - PubMed
    1. Annu Rev Med. 1994;45:491-503 - PubMed
    1. Blood. 1990 Dec 15;76(12):2466-9 - PubMed
    1. Acta Neurol Scand. 1991 Nov;84(5):452-5 - PubMed
    1. FASEB J. 1993 Apr 1;7(6):592-600 - PubMed

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