Telomerase is a true reverse transcriptase. A review
- PMID: 9467843
Telomerase is a true reverse transcriptase. A review
Abstract
Synthesis of telomeric repeats at chromosome ends requires telomerase, a ribonucleoprotein enzyme. The RNA subunit, which contains the template for DNA synthesis, has been identified in many organisms. Recently, the protein subunit that catalyzes telomeric DNA extension has also been identified in Euplotes aediculatus and Saccharomyces cerevisiae. It has sequence and functional characteristics of a reverse transcriptase related to retrotransposon and retroviral reverse transcriptases, so this new family of telomerase subunits has been named TRT (Telomerase Reverse Transcriptase). We find it remarkable that the same type of protein structure required for retroviral replication is now seen to be essential for normal chromosome telomere replication in diverse eukaryotes.
Similar articles
-
Reverse transcriptase motifs in the catalytic subunit of telomerase.Science. 1997 Apr 25;276(5312):561-7. doi: 10.1126/science.276.5312.561. Science. 1997. PMID: 9110970
-
Telomerase is an unusual RNA-containing enzyme. A review.Biochemistry (Mosc). 1997 Nov;62(11):1206-15. Biochemistry (Mosc). 1997. PMID: 9467844 Review.
-
Ever shorter telomere 1 (EST1)-dependent reverse transcription by Candida telomerase in vitro: evidence in support of an activating function.Proc Natl Acad Sci U S A. 2003 May 13;100(10):5718-23. doi: 10.1073/pnas.1036868100. Epub 2003 Apr 25. Proc Natl Acad Sci U S A. 2003. PMID: 12716976 Free PMC article.
-
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT.Nat Genet. 1997 Dec;17(4):498-502. doi: 10.1038/ng1297-498. Nat Genet. 1997. PMID: 9398860
-
The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review.Biochemistry (Mosc). 1997 Nov;62(11):1196-201. Biochemistry (Mosc). 1997. PMID: 9467842 Review.
Cited by
-
Guanine tetraplex topology of human telomere DNA is governed by the number of (TTAGGG) repeats.Nucleic Acids Res. 2005 Oct 12;33(18):5851-60. doi: 10.1093/nar/gki898. Print 2005. Nucleic Acids Res. 2005. PMID: 16221978 Free PMC article.
-
Replication proteins influence the maintenance of telomere length and telomerase protein stability.Mol Cell Biol. 2003 May;23(9):3031-42. doi: 10.1128/MCB.23.9.3031-3042.2003. Mol Cell Biol. 2003. PMID: 12697806 Free PMC article.
-
Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.Carcinogenesis. 2011 Sep;32(9):1315-23. doi: 10.1093/carcin/bgr116. Epub 2011 Jun 21. Carcinogenesis. 2011. PMID: 21693539 Free PMC article.
-
Expression of mutated Paramecium telomerase RNAs in vivo leads to templating errors that resemble those made by retroviral reverse transcriptase.Mol Cell Biol. 1999 Apr;19(4):2887-94. doi: 10.1128/MCB.19.4.2887. Mol Cell Biol. 1999. PMID: 10082555 Free PMC article.
-
Telomerase Cajal body protein 1 depletion inhibits telomerase trafficking to telomeres and induces G1 cell cycle arrest in A549 cells.Oncol Lett. 2014 Sep;8(3):1009-1016. doi: 10.3892/ol.2014.2306. Epub 2014 Jul 2. Oncol Lett. 2014. PMID: 25120649 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases