Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997;42(4):403-8.
doi: 10.1007/BF02816958.

Immunomodulatory effects of Bacillus firmus

I Trebichavský  1 , M Mára, J Sinkora, I Splíchal, R Stĕpánková
Affiliations

Immunomodulatory effects of Bacillus firmus

I Trebichavský et al. Folia Microbiol (Praha). 1997.

Abstract

3-day-old miniature piglets were stimulated in vivo with Bacillus firmus by the intraperitoneal or intragastric route for 1 d. Cells containing IgA and IgG2 were detected in the ileum in all stimulated but not in control animals. The frequency of blood CD3+ cells increased after intraperitoneal administration of B. firmus, the ratio of polymorphonuclears to lymphocytes increased in all stimulated piglets. B. firmus induced antitumor immunity in rats with transplanted Yoshida sarcoma cells. Granular lymphocytes and dead tumor cells were found in peritoneal exudate of stimulated animals. B. firmus induced IFN-gamma synthesis in human blood lymphocytes stimulated in vitro for 1 d. The amount of TNF-alpha produced by these stimulated human peripheral blood mononuclears (PBMC) was lower than that of PBMC stimulated with some other bacterial immunomodulators. Cells containing TGF-beta or IL-8 were not found in human PBMC stimulated with B. firmus.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Immunol Today. 1996 Jan;17(1):30-9 - PubMed
    1. Folia Microbiol (Praha). 1992;37(6):455-60 - PubMed
    1. Immunology. 1996 Aug;88(4):611-7 - PubMed
    1. Folia Microbiol (Praha). 1994;39(2):147-51 - PubMed
    1. Immunol Rev. 1991 Feb;119:65-93 - PubMed

Publication types

MeSH terms

LinkOut - more resources