Review
doi: 10.1016/s0959-4388(97)80089-x.
Presenilins and Alzheimer's disease
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- PMID: 9384549
- DOI: 10.1016/s0959-4388(97)80089-x
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Review
Presenilins and Alzheimer's disease
Curr Opin Neurobiol.
1997 Oct.
Abstract
Mutations in the genes encoding the presenilins cause the majority of early-onset cases of Alzheimer's disease (AD). The identification of the presenilin genes has provided new opportunities for elucidating the molecular mechanisms underlying the etiology and pathogenesis of AD. Recent progress has been made in attempts to understand the normal and pathological functions of the presenilins, emphasizing the effects of presenilin familial AD mutations on the amyloid beta-protein precursor, the presenilins themselves, and apoptotic cell death.
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