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Review
. 1997 Oct;55(10):2666-9.

[Mechanism of the induction of apoptosis by influenza virus infection]

[Article in Japanese]
M Matsumura  1 , Y Nakanishi
Affiliations
  • PMID: 9360388
Review

[Mechanism of the induction of apoptosis by influenza virus infection]

[Article in Japanese]
M Matsumura et al. Nihon Rinsho. 1997 Oct.

Abstract

Influenza virus-infected HeLa cells show phosphatidylserine externalization, chromatin condensation, increase of membrane permeability, and inactivation of a mitochondrial enzyme(s), which are collectively referred as apoptosis. The amount of cell surface Fas and its ligand increases before the onset of apoptosis and the presence of a Fas-ligand-antagonizing antibody inhibits apoptosis. Since virus-infected cells simultaneously express Fas and Fas-ligand, it is likely that apoptosis is induced when the cells come into contact with each other. We expect that apoptotic death of influenza virus-infected cells contributes to elimination of the virus from host organism.

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