Review
doi: 10.1016/s0014-5793(97)00984-8.
A cisternal maturation mechanism can explain the asymmetry of the Golgi stack
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- PMID: 9315681
- DOI: 10.1016/s0014-5793(97)00984-8
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Review
A cisternal maturation mechanism can explain the asymmetry of the Golgi stack
FEBS Lett.
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Free article
Abstract
Morphological data suggest that Golgi cisternae form at the cis-face of the stack and then progressively mature into trans-cisternae. However, other studies indicate that COPI vesicles transport material between Golgi cisternae. These two observations can be reconciled by assuming that cisternae carry secretory cargo through the stack in the anterograde direction, while COPI vesicles transport Golgi enzymes in the retrograde direction. This model provides a mechanism for cisternal maturation. If Golgi enzymes compete with one another for packaging into COPI vesicles, we can account for the asymmetric distribution of enzymes across the stack.
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