Review
doi: 10.1016/s0959-437x(97)80072-x.
From receptor to nucleus: the Smad pathway
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- PMID: 9309176
- DOI: 10.1016/s0959-437x(97)80072-x
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Review
From receptor to nucleus: the Smad pathway
Curr Opin Genet Dev.
1997 Aug.
Abstract
The transforming growth factor-beta (TGF-beta) superfamily plays a central role in the specification and patterning of cells in the early embryo. Several years ago, the TGF-beta s were shown to signal through serine/threonine receptor kinases. Now, with the identification of Smad proteins, we can trace the TGF-beta signal transduction pathway from the receptors into the nucleus.
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