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Review
. 1997 Sep:52 Suppl 2:S9-12.

Molecular genetics of Alzheimer's disease

A M Goate  1
Affiliations
  • PMID: 9307578
Review

Molecular genetics of Alzheimer's disease

A M Goate. Geriatrics. 1997 Sep.

Abstract

Genetic studies have led to the identification of three genes which, when mutated, cause familial forms of Alzheimer's disease (AD): the beta-amyloid precursor protein gene (APP), presenilin 1 (PS-1) and presenilin 2 (PS-2). Association studies have also shown that the epsilon 4 allele of the apolipoprotein E (ApoE) gene increases risk for AD in a dose-dependent manner in both familial and sporadic forms of AD. It is likely that there are additional AD risk factors, both genetic and environmental, as 50% of sporadic AD cases have no ApoE epsilon 4 alleles, and families showing mendelian inheritance of AD exist in which there are no mutations in any of the known genes.

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