Nonfilamentous C. albicans mutants are avirulent
- PMID: 9298905
- DOI: 10.1016/s0092-8674(00)80358-x
Nonfilamentous C. albicans mutants are avirulent
Abstract
Candida albicans and Saccharomyces cerevisiae switch from a yeast to a filamentous form. In Saccharomyces, this switch is controlled by two regulatory proteins, Ste12p and Phd1p. Single-mutant strains, ste12/ste12 or phd1/phd1, are partially defective, whereas the ste12/ste12 phd1/phd1 double mutant is completely defective in filamentous growth and is noninvasive. The equivalent cph1/cph1 efg1/efg1 double mutant in Candida (Cph1p is the Ste12p homolog and Efg1p is the Phd1p homolog) is also defective in filamentous growth, unable to form hyphae or pseudohyphae in response to many stimuli, including serum or macrophages. This Candida cph1/cph1 efg1/efg1 double mutant, locked in the yeast form, is avirulent in a mouse model.
Similar articles
-
Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog.Science. 1994 Dec 9;266(5191):1723-6. doi: 10.1126/science.7992058. Science. 1994. PMID: 7992058
-
Cph1p negatively regulates MDR1 involved in drug resistance in Candida albicans.Int J Antimicrob Agents. 2015 Jun;45(6):617-21. doi: 10.1016/j.ijantimicag.2015.01.017. Epub 2015 Mar 6. Int J Antimicrob Agents. 2015. PMID: 25802233
-
Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans.Mol Cell Biol. 2000 Dec;20(23):8696-708. doi: 10.1128/MCB.20.23.8696-8708.2000. Mol Cell Biol. 2000. PMID: 11073971 Free PMC article.
-
Control of pseudohyphae formation in Saccharomyces cerevisiae.FEMS Microbiol Rev. 2001 Jan;25(1):107-23. doi: 10.1111/j.1574-6976.2001.tb00573.x. FEMS Microbiol Rev. 2001. PMID: 11152942 Review.
-
Co-regulation of pathogenesis with dimorphism and phenotypic switching in Candida albicans, a commensal and a pathogen.Int J Med Microbiol. 2002 Oct;292(5-6):299-311. doi: 10.1078/1438-4221-00215. Int J Med Microbiol. 2002. PMID: 12452278 Review.
Cited by
-
A modified culture medium and hyphae isolation method can increase quality of the RNA extracted from mycelia of a dimorphic fungal species.Curr Genet. 2021 Oct;67(5):823-830. doi: 10.1007/s00294-021-01181-4. Epub 2021 Apr 10. Curr Genet. 2021. PMID: 33837814 Free PMC article.
-
Raft-like membrane domains in pathogenic microorganisms.Curr Top Membr. 2015;75:233-68. doi: 10.1016/bs.ctm.2015.03.005. Epub 2015 Apr 11. Curr Top Membr. 2015. PMID: 26015285 Free PMC article. Review.
-
Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism.Cell Host Microbe. 2021 Jun 9;29(6):1002-1013.e9. doi: 10.1016/j.chom.2021.03.019. Epub 2021 Apr 28. Cell Host Microbe. 2021. PMID: 33915113 Free PMC article.
-
Sodium New Houttuyfonate Inhibits Candida albicans Biofilm Formation by Inhibiting the Ras1-cAMP-Efg1 Pathway Revealed by RNA-seq.Front Microbiol. 2020 Aug 25;11:2075. doi: 10.3389/fmicb.2020.02075. eCollection 2020. Front Microbiol. 2020. PMID: 32983053 Free PMC article.
-
Purpurin suppresses Candida albicans biofilm formation and hyphal development.PLoS One. 2012;7(11):e50866. doi: 10.1371/journal.pone.0050866. Epub 2012 Nov 30. PLoS One. 2012. PMID: 23226409 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
