Eukaryotic initiation factor 5A activity and HIV-1 Rev function
- PMID: 9285095
- DOI: 10.1159/000109118
Eukaryotic initiation factor 5A activity and HIV-1 Rev function
Abstract
Eukaryotic initiation factor 5A (eIF-5A) is the only cellular protein known to contain the unusual amino acid hypusine, a modification that appears to be required for cell proliferation. This hypusine-modified protein stimulates synthesis of methionyl-puromycin in an in vitro assay which mimics the formation of the first peptide bond during protein synthesis, although the exact role of eIF-5A in vivo is still unknown. The unexpected finding that eIF-5A is a cellular cofactor of the HIV-1 Rev trans-activator protein may, however, provide a novel opportunity to reveal precisely what function eIF-5A performs in eukaryotic cells. In this review article, we first present a brief description of HIV-1 Rev function, followed by an overview of the data that identified eIF-5A as a Rev cofactor and, finally, discuss novel findings with respect to cellular eIF-5A activities.
Similar articles
-
Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification.Biol Signals. 1997 May-Jun;6(3):166-74. doi: 10.1159/000109123. Biol Signals. 1997. PMID: 9285100
-
Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A.Science. 1996 Mar 29;271(5257):1858-60. doi: 10.1126/science.271.5257.1858. Science. 1996. PMID: 8596953
-
The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2.Genomics. 1995 Feb 10;25(3):749-52. doi: 10.1016/0888-7543(95)80025-h. Genomics. 1995. PMID: 7759117
-
Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation.Biofactors. 1993 May;4(2):95-104. Biofactors. 1993. PMID: 8347280 Review.
-
Hypusine is essential for eukaryotic cell proliferation.Biol Signals. 1997 May-Jun;6(3):115-23. doi: 10.1159/000109117. Biol Signals. 1997. PMID: 9285094 Review.
Cited by
-
Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling.Genetics. 2002 Feb;160(2):393-405. doi: 10.1093/genetics/160.2.393. Genetics. 2002. PMID: 11861547 Free PMC article.
-
Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].J Biol Chem. 2006 May 12;281(19):13217-13225. doi: 10.1074/jbc.M601081200. Epub 2006 Mar 13. J Biol Chem. 2006. PMID: 16533814 Free PMC article.
-
The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei.Biomolecules. 2023 May 9;13(5):803. doi: 10.3390/biom13050803. Biomolecules. 2023. PMID: 37238673 Free PMC article. Review.
-
Functional characterization of the Arabidopsis eukaryotic translation initiation factor 5A-2 that plays a crucial role in plant growth and development by regulating cell division, cell growth, and cell death.Plant Physiol. 2007 Jul;144(3):1531-45. doi: 10.1104/pp.107.098079. Epub 2007 May 18. Plant Physiol. 2007. PMID: 17513484 Free PMC article.
-
Synthetic lethality between eIF5A and Ypt1 reveals a connection between translation and the secretory pathway in yeast.Mol Genet Genomics. 2008 Sep;280(3):211-21. doi: 10.1007/s00438-008-0357-y. Epub 2008 Jun 21. Mol Genet Genomics. 2008. PMID: 18568365
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources