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. 1997 Aug;41(8):1825-9.
doi: 10.1128/AAC.41.8.1825.

Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B

N Mozaffarian  1 , J W Berman, A Casadevall
Affiliations

Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B

N Mozaffarian et al. Antimicrob Agents Chemother. 1997 Aug.

Abstract

Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage-like J774.16 cells in a dose-dependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically. In all cases, AmB required gamma interferon; C. neoformans cells were unable to elicit nitrite, with or without AmB.

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