Review
doi: 10.1159/000237614.
Functional role of CD40 and its ligand
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- PMID: 9250584
- DOI: 10.1159/000237614
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Review
Functional role of CD40 and its ligand
Int Arch Allergy Immunol.
1997 Aug.
Abstract
CD40, a cell surface receptor which belongs to the TNF-R family, was first identified and functionally characterized on B lymphocytes. In recent years, CD40 has been found expressed on other cells, including monocytes, dendritic cells, endothelial cells and epithelial cells and is now thought to play a more general role in immune regulation. The present paper reviews recent developments about CD40, with main emphasis on: (1) structure and expression of CD40 and its ligand; (2) CD40 signal transduction; (3) in vitro function of CD40 on different cell types, and (4) in vivo functions of CD40/CD40L interactions.
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