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. 1997 Jul;16(7):650-5.
doi: 10.1076/ceyr.16.7.650.5052.

Abnormal naive and memory T lymphocyte subsets in the peripheral blood of patients with uveitis

K Ohta  1 , K Norose, X C Wang, S Ito, N Yoshimura
Affiliations

Abnormal naive and memory T lymphocyte subsets in the peripheral blood of patients with uveitis

K Ohta et al. Curr Eye Res. 1997 Jul.

Abstract

Purpose: To better define the role of lymphocytes in the pathogenesis of uveitis, we studied the expression of memory and naive cell markers on T lymphocytes from peripheral blood.

Methods: Surface antigens on T lymphocytes obtained from peripheral blood of 27 patients with uveitis, including 12 patients with Behçet's disease (BD), 7 patients with Vogt-Koyanagi-Harada disease (VKH), and 8 patients with idiopathic uveitis (IU), were detected by three-color flow cytometric analysis. Lymphocytes from 14 age-matched healthy control subjects were similarly evaluated.

Results: The percentage of T lymphocytes that were CD4+CD29+ lymphocytes (memory cells) was high in all patients with uveitis, while that of CD4+CD45RA+ lymphocytes (naive cells) was lower in patients with BD and VKH, although the difference was not statistically significant. The percentage of CD29+ cells within CD3+CD4+ cell population was significantly higher in patients with BD and VKH than in the controls (p < 0.01), and the percentage of CD45RA+ cells was significantly lower in BD patients than in controls (p < 0.01). The T lymphocyte subsets in patients with IU were similar to the controls.

Conclusions: These results show an abnormal distribution of T lymphocytes in patients with uveitis associated with an underlying systemic disease.

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