Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Apr:11 Suppl 3:545-7.

Dual phasic suppression of viral replication following de novo human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes of asymptomatic HIV-1 carriers

M Kannagi  1 , T Nakamura, H Akari, M J Kuroda, M Fujii, S Oka, A Iwamoto, T Kurata, D Higashi, S Harada
Affiliations
  • PMID: 9209452

Dual phasic suppression of viral replication following de novo human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes of asymptomatic HIV-1 carriers

M Kannagi et al. Leukemia. 1997 Apr.

Abstract

Replication of human immunodeficiency virus type 1 (HIV-1) is suppressed in asymptomatic HIV-1 carriers (ACs). By using an in vitro experimental system, the mechanism of this suppression was investigated. Following in vitro infection of a laboratory HIV-1 strain, the peripheral blood mononuclear cells (PBMC) of ACs transiently supported a low level of viral replication, then the virus production rapidly decreased. PCR analysis revealed that HIV-1 proviral DNA integrated in the PBMC of ACs following infection gradually decreased. Such tapering consequences of in vitro HIV-1 infection in the PBMC of ACs were abrogated by depletion of CD8+ T cells from the culture. Furthermore, the viruses subsequently produced by the PBMC of an AC were less able to replicate than the virus produced by CD8+ cell-depleted PBMC of the same donor. These observations suggested that the CD8+ T cell-mediated suppression of HIV-1 replication in ACs may involve both cytocidal and cytostatic mechanisms: the former kills the cells producing viruses, and the latter inhibits viral spread by reducing viral infectivity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • The CD8+ T Cell Noncytotoxic Antiviral Responses.
    Morvan MG, Teque FC, Locher CP, Levy JA. Morvan MG, et al. Microbiol Mol Biol Rev. 2021 May 12;85(2):e00155-20. doi: 10.1128/MMBR.00155-20. Print 2021 May 19. Microbiol Mol Biol Rev. 2021. PMID: 33980586 Free PMC article. Review.

Publication types

MeSH terms

LinkOut - more resources