Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices
- PMID: 9175620
- DOI: 10.1016/s0028-3908(97)00014-2
Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices
Abstract
The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.
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