doi: 10.1074/jbc.272.21.13793.
Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins
Affiliations
- PMID: 9153235
- DOI: 10.1074/jbc.272.21.13793
Item in Clipboard
Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins
J Biol Chem.
.
Free article
Abstract
Caveolae are plasmalemmal microdomains that are involved in vesicular trafficking and signal transduction. We have sought to identify novel integral membrane proteins of caveolae. Here we describe the identification and molecular cloning of flotillin. By several independent methods, flotillin behaves as a resident integral membrane protein component of caveolae. Furthermore, we have identified epidermal surface antigen both as a flotillin homologue and as a resident caveolar protein. Significantly, flotillin is a marker for the Triton-insoluble, buoyant membrane fraction in brain, where to date mRNA species for known caveolin gene family members have not been detected.
Similar articles
-
Identification of reggie-1 and reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons.J Neurobiol. 1998 Dec;37(4):502-23. doi: 10.1002/(sici)1097-4695(199812)37:4<502::aid-neu2>3.0.co;2-s. J Neurobiol. 1998. PMID: 9858255
-
Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals.Int J Biochem Cell Biol. 2001 Jan;33(1):53-64. doi: 10.1016/s1357-2725(00)00069-8. Int J Biochem Cell Biol. 2001. PMID: 11167132
-
Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster.Gene. 1998 Apr 14;210(2):229-37. doi: 10.1016/s0378-1119(98)00064-x. Gene. 1998. PMID: 9573373
-
Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe.J Biol Chem. 1999 Apr 30;274(18):12702-9. doi: 10.1074/jbc.274.18.12702. J Biol Chem. 1999. PMID: 10212252
-
Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation.J Cell Biochem. 1999 Oct 1;75(1):147-59. J Cell Biochem. 1999. PMID: 10462713
Cited by
-
Structure of the flotillin complex in a native membrane environment.Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2409334121. doi: 10.1073/pnas.2409334121. Epub 2024 Jul 10. Proc Natl Acad Sci U S A. 2024. PMID: 38985763 Free PMC article.
-
Clear Cell Renal Carcinoma: MicroRNAs With Efficacy in Preclinical In Vivo Models.Cancer Genomics Proteomics. 2021 May-Jun;18(3 Suppl):349-368. doi: 10.21873/cgp.20265. Epub 2021 May 15. Cancer Genomics Proteomics. 2021. PMID: 33994361 Free PMC article. Review.
-
Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression.Biochem J. 2004 Mar 1;378(Pt 2):509-18. doi: 10.1042/BJ20031100. Biochem J. 2004. PMID: 14599293 Free PMC article.
-
Migration of nerve growth cones requires detergent-resistant membranes in a spatially defined and substrate-dependent manner.J Cell Biol. 2002 Dec 23;159(6):1097-108. doi: 10.1083/jcb.200209077. Epub 2002 Dec 23. J Cell Biol. 2002. PMID: 12499360 Free PMC article.
-
Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease.J Biol Chem. 2009 Aug 14;284(33):21899-21907. doi: 10.1074/jbc.M109.019521. Epub 2009 Jun 19. J Biol Chem. 2009. PMID: 19542222 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
Grants and funding
etc
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
