Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Jun;71(6):4809-14.
doi: 10.1128/JVI.71.6.4809-4814.1997.

Human immunodeficiency virus-associated vasculopathy in transgenic mice

B T Tinkle  1 , L Ngo, P A Luciw, T Maciag, G Jay
Affiliations

Human immunodeficiency virus-associated vasculopathy in transgenic mice

B T Tinkle et al. J Virol. 1997 Jun.

Abstract

There is substantial clinical evidence for the development of vascular disorders in human immunodeficiency virus (HIV)-infected individuals, particularly in the form of vasculitis. Transgenic mice carrying a replication-defective HIV-1 provirus with selective deletion of the gag, pol, and env genes developed extensive vasculopathy. Restricted expression of HIV nonstructural genes in smooth muscle cells was accompanied by the migration and proliferation of these cells in blood vessels of all sizes and at different body sites. The frequent infiltration observed in the hypertrophic vessel walls occurred predominantly in the adventitia and was composed of primarily T cells and occasionally plasma cells. The intimal thickening generated significant luminal narrowing in some vessels, and the restricted blood flow led to ischemia in the affected tissues. Interestingly, the endothelium did not appear to support HIV gene expression or be involved in the pathological process. This transgenic model provides an opportunity to dissect the mechanism underlying HIV-associated vasculopathy.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Clin Infect Dis. 1993 Sep;17(3):360-3 - PubMed
    1. Am J Pathol. 1993 Oct;143(4):987-1002 - PubMed
    1. South Med J. 1995 Jan;88(1):82-6 - PubMed
    1. Pediatr Pathol. 1994 Nov-Dec;14(6):919-25 - PubMed
    1. Arterioscler Thromb Vasc Biol. 1995 Dec;15(12):2254-64 - PubMed

Publication types