The HGF receptor family: unconventional signal transducers for invasive cell growth
- PMID: 9135079
- DOI: 10.1046/j.1365-2443.1996.37037.x
The HGF receptor family: unconventional signal transducers for invasive cell growth
Abstract
The HGF receptor family includes tyrosine kinases encoded by three oncogenes: MET, SEA and RON. The members of this gene family share a unique functional feature: they mediate cell dissociation and motility ('scattering') in physiological conditions, and invasiveness in their activated versions. The Met, Ron and Sea receptors display a distinctive signal transduction behaviour. Unlike conventional growth factor receptors, their cytoplasmic tails contain a multifunctional docking site. Upon autophosphorylation, this sequence simultaneously binds and activates multiple SH2-containing transducers, including Ras and PI 3-kinase. A deregulated activation of this 'supersite' triggers a dramatic pleiotropic signal which is responsible for invasive cell growth.
Similar articles
-
STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.EMBO J. 1996 Nov 1;15(21):5866-75. EMBO J. 1996. PMID: 8918464 Free PMC article.
-
Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth.Exp Cell Res. 1999 Nov 25;253(1):88-99. doi: 10.1006/excr.1999.4684. Exp Cell Res. 1999. PMID: 10579914 Review.
-
The hepatocyte growth factor and its receptor.Stem Cells. 1993 Jul;11 Suppl 2:22-30. doi: 10.1002/stem.5530110805. Stem Cells. 1993. PMID: 8401259 Review.
-
The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro.Mol Biol Cell. 1996 Apr;7(4):495-504. doi: 10.1091/mbc.7.4.495. Mol Biol Cell. 1996. PMID: 8730094 Free PMC article.
-
Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells.EXS. 1993;65:131-65. EXS. 1993. PMID: 8380735 Review.
Cited by
-
Overexpression of the hepatocyte growth factor (HGF) receptor (Met) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive/malignant human musculoskeletal tumors.Am J Pathol. 2000 Mar;156(3):821-9. doi: 10.1016/S0002-9440(10)64950-4. Am J Pathol. 2000. PMID: 10702398 Free PMC article.
-
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.EMBO J. 1997 Jul 1;16(13):3877-88. doi: 10.1093/emboj/16.13.3877. EMBO J. 1997. PMID: 9233798 Free PMC article.
-
A point mutation in the MET oncogene abrogates metastasis without affecting transformation.Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13868-72. doi: 10.1073/pnas.94.25.13868. Proc Natl Acad Sci U S A. 1997. PMID: 9391119 Free PMC article.
-
Detection of MET and SOX2 amplification by quantitative real-time PCR in non-small cell lung carcinoma.Oncol Lett. 2011 Mar;2(2):257-264. doi: 10.3892/ol.2010.229. Epub 2010 Dec 23. Oncol Lett. 2011. PMID: 22866074 Free PMC article.
-
A comparison of the pharmacokinetics of the anticancer MET inhibitor foretinib free base tablet formulation to bisphosphate salt capsule formulation in patients with solid tumors.Invest New Drugs. 2012 Feb;30(1):327-34. doi: 10.1007/s10637-010-9536-x. Epub 2010 Sep 15. Invest New Drugs. 2012. PMID: 20842406 Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
