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Review
. 1996 Sep;13(3):133-40.
doi: 10.1007/BF02990841.

Granulocyte-macrophage colony-stimulating factor and the immune system

P E Tarr  1
Affiliations
Review

Granulocyte-macrophage colony-stimulating factor and the immune system

P E Tarr. Med Oncol. 1996 Sep.

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional cytokine currently used for the reversal of neutropenia associated with cytotoxic chemotherapy, bone marrow and haemopoietic stem cell transplantation. GM-CSF also modulates the function of differentiated white blood cells. In the context of local inflammatory responses, GM-CSF stimulates macrophages for antimicrobial and antitumor effects. GM-CSF further enhances healing and repair by its actions on fibroblasts and epidermal cells. GM-CSF is the pivotal mediator of the maturation and function of dendritic cells, the most important cell type for the induction of primary T cell immune responses. GM-CSF may enhance antibody dependent cellular cytotoxicity (ADCC) in several cell types, and the generation and cytotoxicity of natural killer (NK) cells. On this basis, GM-CSF may be useful for inducing or augmenting antibody responses to antimicrobial vaccines, to enhance killing of intracellular microorganisms, to accelerate epidermal and mucosal wound healing, and to stimulate protective immunity against tumors.

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References

    1. Vaccine. 1996 Sep;14(13):1199-204 - PubMed
    1. J Exp Med. 1996 Apr 1;183(4):1287-92 - PubMed
    1. Blood. 1993 Jun 15;81(12):3474-9 - PubMed
    1. J Exp Med. 1996 Jan 1;183(1):317-22 - PubMed
    1. J Urol. 1994 Mar;151(3):622-8 - PubMed

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