Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 May;71(5):3776-87.
doi: 10.1128/JVI.71.5.3776-3787.1997.

Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation

K A Page  1 , W C van Schooten, M B Feinberg
Affiliations

Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation

K A Page et al. J Virol. 1997 May.

Abstract

We have developed an in vitro model to study the influence that human immunodeficiency virus type 1 (HIV-1) may have on the ability of T cells to respond to antigenic challenge. We have examined consequences of HIV-1 gene expression on T-cell activation in antigen-dependent T cells that have stably integrated copies of replication-defective proviral HIV-1. Virus production by HIV-infected, antigen-dependent T cells was induced in response to antigenic stimulation and then decreased as infected cells returned to a state of quiescence. Contrary to the predictions of models proposing that Nef alters signal transduction pathways in T lymphocytes and thereby alters cellular activation, Nef expression in antigen-dependent T-cell clones did not influence their proliferative responses to low or intermediate concentrations of antigen and did not affect other measures of T-cell activation, such as induction of interleukin 2 receptor alpha-chain expression and cytokine production. In addition, we found no evidence for alteration of T-cell responsiveness to antigen by the gag, pol, vif, tat, or rev gene of HIV-1.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Nat Med. 1995 Dec;1(12):1284-90 - PubMed
    1. J Exp Med. 1995 Dec 1;182(6):1727-37 - PubMed
    1. J Immunol. 1996 Jan 1;156(1):360-70 - PubMed
    1. Cell. 1986 Sep 12;46(6):807-17 - PubMed
    1. Science. 1987 Nov 6;238(4828):800-2 - PubMed

Publication types

LinkOut - more resources