Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997;11(1):17-22.
doi: 10.1002/(SICI)1098-2825(1997)11:1<17::AID-JCLA4>3.0.CO;2-H.

New molecular diagnostic tests for two congenital forms of anemia

A D Auerbach  1 , P C Verlander, K E Brown, J M Liu
Affiliations
Review

New molecular diagnostic tests for two congenital forms of anemia

A D Auerbach et al. J Clin Lab Anal. 1997.

Abstract

Congenital hypoplastic anemias are a rare and heterogeneous group of disorders. This paper reviews new molecular diagnostic tests in two distinct forms of congenital anemias, anemia due to transplacental infection with B19 parvovirus and Fanconi anemia. In both instances, molecular assays making use of amplification of DNA by the polymerase chain reaction have been used to diagnose either a specific viral infection or gene mutation responsible for a disorder. Recognition of these entities has important prognostic and therapeutic implications.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Brown KE, Young NS, Liu JM: Molecular, cellular and clinical aspects of parvovirus B19 infection. Crit Rev Oncol Hematol 16: 1–31, 1994. - PubMed
    1. Brown KE, Green SW, Antunez de Mayolo J, Bellanti JA, Smith SD, Smith TJ, Young NS: Congenital anemia after transplacental B19 parvovirus infection. Lancet 343: 895–896, 1994. - PubMed
    1. Lipton JM: Congenital pure red cell aplasia In Hematology: Basic Principles and Practice. 2nd ed. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, eds. Churchill Livingstone, New York, 1995, p 365.
    1. Fanconi G: Familial constitutional panmyelocytopathy, Fanconi's anemia (F.A.). I. Clinical aspects. Semin Hematol 4: 233–240, 1967. - PubMed
    1. Auerbach AD, Allen RG: Leukemia and preleukemia in Fanconi anemia patients: A review of the literature and report of the International Fanconi Anemia Registry. Cancer Genet Cytogenet 51: 1–12, 1991. - PubMed

Publication types