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. 1977 Aug;12(2):298-300.
doi: 10.1128/AAC.12.2.298.

Cytotoxicity and cell cycle specificity of homoharringtonine

D M Baaske, P Heinstein

Cytotoxicity and cell cycle specificity of homoharringtonine

D M Baaske et al. Antimicrob Agents Chemother. 1977 Aug.

Abstract

The plant alkaloid, homoharringtonine, isolated from Cephalotaxus harringtonia is cytotoxic to HeLa, KB, and L cells growing in monolayer cell cultures. This effect appears to be cell-cycle specific. In synchronized KB cells, protein synthesis was preferentially inhibited in the G(1) and G(2) phases (70 and 45% inhibition, respectively) as might be expected for a protein-synthesis inhibitor.

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