Review
doi: 10.1111/j.1753-4887.1996.tb03878.x.
Leptin: the weight-reducing plasma protein encoded by the obese gene
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- PMID: 8935220
- DOI: 10.1111/j.1753-4887.1996.tb03878.x
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Review
Leptin: the weight-reducing plasma protein encoded by the obese gene
Nutr Rev.
1996 Mar.
Abstract
Leptin, the protein encoded by the recently cloned obese gene, has the properties of a hormone released by adipose tissue, regulating appetite and energy expenditure. Injected leptin reduces body weight and food intake in mice, and in obese, diabetic mice (with a mutated obese gene), it also reduces plasma insulin and glucose. Leptin release is stimulated by insulin; leptin appears to act on the hypothalamus by inhibiting the release of the neuropeptide Y.
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