Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

doi:10.1016/0966-842X(96)10059-7

Review

. 1996 Oct;4(10):394-400.

doi: 10.1016/0966-842X(96)10059-7.

Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

M K Slifka¹, R Ahmed

Affiliations

PMID: 8899965
PMCID: PMC7133309
DOI: 10.1016/0966-842X(96)10059-7

Review

Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

M K Slifka et al. Trends Microbiol. 1996 Oct.

. 1996 Oct;4(10):394-400.

doi: 10.1016/0966-842X(96)10059-7.

Authors

M K Slifka¹, R Ahmed

Affiliation

¹ Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30307, USA.

PMID: 8899965
PMCID: PMC7133309
DOI: 10.1016/0966-842X(96)10059-7

Abstract

Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.

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Comment in

B cell longevity and immunological memory.
Michie CA, Lampert IA. Michie CA, et al. Trends Microbiol. 1997 May;5(5):180-1. doi: 10.1016/S0966-842X(97)85011-1. Trends Microbiol. 1997. PMID: 9160504 No abstract available.

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References

1. Ahmed R., Gray D. Science. 1996;272:54–60. - PubMed
1. Kempe C.H. Bull. WHO. 1961;25:41–48. - PMC - PubMed
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[1] Ahmed R., Gray D. Science. 1996;272:54–60. - PubMed

[2] Ahmed R., Gray D. Science. 1996;272:54–60. - PubMed

[3] Kempe C.H. Bull. WHO. 1961;25:41–48. - PMC - PubMed

[4] Kempe C.H. Bull. WHO. 1961;25:41–48. - PMC - PubMed

[5] Krugman S. New Engl. J. Med. 1963;269:195–201. - PubMed

[6] Krugman S. New Engl. J. Med. 1963;269:195–201. - PubMed

[7] McDonald J.C. Br. Med. J. 1963;2:416–418. - PMC - PubMed

[8] McDonald J.C. Br. Med. J. 1963;2:416–418. - PMC - PubMed

[9] Vieira P., Rajewsky K. Eur. J. Immunol. 1988;18:313–316. - PubMed

[10] Vieira P., Rajewsky K. Eur. J. Immunol. 1988;18:313–316. - PubMed

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Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

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Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

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