Review
The multiple roles of transcription/repair factor TFIIH
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- PMID: 8870499
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Review
The multiple roles of transcription/repair factor TFIIH
Trends Biochem Sci.
1996 Sep.
Abstract
TFIIH is by far the most complex of the basal RNA polymerase II transcription factors. It is a protein kinase, a bi-directional DNA helicase and is essential for both transcription and nucleotide excision repair (NER). Furthermore, the factor can activate cyclin-dependent kinases and so might play a role in cell-cycle regulation. The recent elucidation of the subunit composition of TFIIH has shown an extraordinary conservation of its structure from yeast to human.
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