Review
doi: 10.1146/annurev.bi.65.070196.000533.
Mismatch repair in replication fidelity, genetic recombination, and cancer biology
Affiliations
- PMID: 8811176
- DOI: 10.1146/annurev.bi.65.070196.000533
Item in Clipboard
Review
Mismatch repair in replication fidelity, genetic recombination, and cancer biology
Annu Rev Biochem.
1996.
Abstract
Mismatch repair stabilizes the cellular genome by correcting DNA replication errors and by blocking recombination events between divergent DNA sequences. The reaction responsible for strand-specific correction of mispaired bases has been highly conserved during evolution, and homologs of bacterial MutS and MutL, which play key roles in mismatch recognition and initiation of repair, have been identified in yeast and mammalian cells. Inactivation of genes encoding these activities results in a large increase in spontaneous mutability, and in the case of mice and men, predisposition to tumor development.
Similar articles
-
[Mismatch repair protein].Gan To Kagaku Ryoho. 1997 Sep;24(11):1392-400. Gan To Kagaku Ryoho. 1997. PMID: 9309131 Review. Japanese.
-
Mismatch repair ensures fidelity of replication and recombination in the radioresistant organism Deinococcus radiodurans.Mol Genet Genomics. 2004 Nov;272(4):460-9. doi: 10.1007/s00438-004-1077-6. Epub 2004 Oct 22. Mol Genet Genomics. 2004. PMID: 15503140
-
DNA mismatch repair and cancer.Front Biosci. 2003 May 1;8:d997-1017. doi: 10.2741/1121. Front Biosci. 2003. PMID: 12700127 Review.
-
Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans.Philos Trans R Soc Lond B Biol Sci. 1995 Jan 30;347(1319):97-103. doi: 10.1098/rstb.1995.0015. Philos Trans R Soc Lond B Biol Sci. 1995. PMID: 7746861 Review.
-
Replication errors: cha(lle)nging the genome.EMBO J. 1998 Nov 16;17(22):6427-36. doi: 10.1093/emboj/17.22.6427. EMBO J. 1998. PMID: 9822589 Free PMC article. Review.
Cited by
-
Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA.Nucleic Acids Res. 2012 Jul;40(12):5448-64. doi: 10.1093/nar/gks138. Epub 2012 Feb 24. Nucleic Acids Res. 2012. PMID: 22367846 Free PMC article.
-
DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae.Genetics. 2013 Apr;193(4):1025-64. doi: 10.1534/genetics.112.145219. Genetics. 2013. PMID: 23547164 Free PMC article. Review.
-
Predictive Biomarkers and Resistance Mechanisms of Checkpoint Inhibitors in Malignant Solid Tumors.Int J Mol Sci. 2024 Sep 6;25(17):9659. doi: 10.3390/ijms25179659. Int J Mol Sci. 2024. PMID: 39273605 Free PMC article. Review.
-
Small-angle X-ray scattering analysis reveals the ATP-bound monomeric state of the ATPase domain from the homodimeric MutL endonuclease, a GHKL phosphotransferase superfamily protein.Extremophiles. 2015 May;19(3):643-56. doi: 10.1007/s00792-015-0745-2. Epub 2015 Mar 26. Extremophiles. 2015. PMID: 25809295
-
Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents.DNA Repair (Amst). 2012 Dec 1;11(12):951-64. doi: 10.1016/j.dnarep.2012.09.004. Epub 2012 Oct 11. DNA Repair (Amst). 2012. PMID: 23062884 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
