Review
doi: 10.1016/s0959-437x(96)80073-6.
Dosage compensation and chromatin structure in Drosophila
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- PMID: 8791531
- DOI: 10.1016/s0959-437x(96)80073-6
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Review
Dosage compensation and chromatin structure in Drosophila
Curr Opin Genet Dev.
1996 Aug.
Free article
Abstract
The past year has brought significant advances in our understanding of the male-specific lethal (msl genes and dosage compensation in Drosophila. The molecular characterization of the msl-2 gene has, to a great extent, solved the question of how msl-mediated dosage compensation is restricted to males. Molecular analyses of the msl genes have substantiated the proposal that the MSL proteins function as a multimeric complex to mediate dosage compensation. The finding that MSL-2 protein has a RING finger and the demonstration that an insulator protein facilitates the dosage compensation of X-linked genes inserted into the autosomes have opened promising avenues to identify the cis-acting dosage-compensation determinants.
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