Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Sep 3;93(18):9881-6.
doi: 10.1073/pnas.93.18.9881.

Identification of potential target genes for the neuron-restrictive silencer factor

C J Schoenherr  1 , A J Paquette, D J Anderson
Affiliations

Identification of potential target genes for the neuron-restrictive silencer factor

C J Schoenherr et al. Proc Natl Acad Sci U S A. .

Abstract

The neuron-restrictive silencer factor (NRSF) represses transcription of several neuronal genes in nonneuronal cells by binding to a 21-bp element called the neuron-restrictive silencer element (NRSE). We have performed data base searches with a composite NRSE to identify additional candidate NRSF target genes. Twenty-two more genes, 17 of which are expressed mainly in neurons, were found to contain NRSE-like sequences. Many of these putative NRSEs bound NRSF in vitro and repressed transcription in vivo. Most of the neuronal genes identified contribute to the basic structural or functional properties of neurons. However, two neuronal transcription factor genes contain NRSEs, suggesting that NRSF may repress neuronal differentiation both directly and indirectly. Functional NRSEs were also found in several nonneuronal genes, implying that NRSF may play a broader role than originally anticipated.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cell. 1988 Jul 1;54(1):5-16 - PubMed
    1. J Biol Chem. 1996 Jun 14;271(24):14221-5 - PubMed
    1. Neuron. 1990 Feb;4(2):223-31 - PubMed
    1. Methods Enzymol. 1990;183:63-98 - PubMed
    1. Neuron. 1990 Apr;4(4):583-94 - PubMed

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources