Review
doi: 10.1016/s0955-0674(96)80007-x.
Control of gene expression by proteolysis
Affiliations
- PMID: 8743884
- DOI: 10.1016/s0955-0674(96)80007-x
Item in Clipboard
Review
Control of gene expression by proteolysis
Curr Opin Cell Biol.
1996 Jun.
Abstract
The proteasome and the small protein ubiquitin are key elements in the intracellular pathway of general protein degradation. Recent evidence shows that the proteasome and other less well defined cytoplasmic proteases can participate in specific events which control inducible gene expression. A number of eukaryotic transcriptional regulators, including NF-kappa B/l kappa B, p53, c-Jun, Notch, sterol regulated element binding proteins and MAT2 alpha, have recently been shown to be regulated by proteolytic events, a regulation which results in the activation or inactivation of gene expression.
Similar articles
-
Inactivation of NF-kappa B inhibitor I kappa B alpha: ubiquitin-dependent proteolysis and its degradation product.Biochem Biophys Res Commun. 1995 Oct 4;215(1):292-301. doi: 10.1006/bbrc.1995.2465. Biochem Biophys Res Commun. 1995. PMID: 7575604
-
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10599-603. doi: 10.1073/pnas.92.23.10599. Proc Natl Acad Sci U S A. 1995. PMID: 7479848 Free PMC article.
-
Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B.Nature. 1993 Sep 9;365(6442):182-5. doi: 10.1038/365182a0. Nature. 1993. PMID: 8371761
-
Human genetic diseases of proteolysis.Hum Mutat. 1999;13(2):87-98. doi: 10.1002/(SICI)1098-1004(1999)13:2<87::AID-HUMU1>3.0.CO;2-K. Hum Mutat. 1999. PMID: 10094566 Review.
-
Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha.Philos Trans R Soc Lond B Biol Sci. 1999 Sep 29;354(1389):1601-9. doi: 10.1098/rstb.1999.0504. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10582246 Free PMC article. Review.
Cited by
-
Trans-regulated silencing and reactivation of TP53 tumor suppressor gene in malignant transformation and its reversion.Jpn J Cancer Res. 2000 Nov;91(11):1111-8. doi: 10.1111/j.1349-7006.2000.tb00893.x. Jpn J Cancer Res. 2000. PMID: 11092975 Free PMC article.
-
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.EMBO J. 2005 Mar 23;24(6):1243-55. doi: 10.1038/sj.emboj.7600596. Epub 2005 Mar 10. EMBO J. 2005. PMID: 15775988 Free PMC article.
-
Involvement of the DNA repair protein hHR23 in p53 degradation.Mol Cell Biol. 2003 Dec;23(24):8960-9. doi: 10.1128/MCB.23.24.8960-8969.2003. Mol Cell Biol. 2003. PMID: 14645509 Free PMC article.
-
The N-end rule: functions, mysteries, uses.Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12142-9. doi: 10.1073/pnas.93.22.12142. Proc Natl Acad Sci U S A. 1996. PMID: 8901547 Free PMC article. Review.
-
Toxoplasma gondii Proteasome Subunit Alpha Type 1 with Chitosan: A Promising Alternative to Traditional Adjuvant.Pharmaceutics. 2021 May 19;13(5):752. doi: 10.3390/pharmaceutics13050752. Pharmaceutics. 2021. PMID: 34069589 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
