Review
doi: 10.2337/diacare.19.4.394.
Fatty acids and insulin resistance
Affiliations
- PMID: 8729171
- DOI: 10.2337/diacare.19.4.394
Item in Clipboard
Review
Fatty acids and insulin resistance
Diabetes Care.
1996 Apr.
Abstract
We have demonstrated that physiological elevations in plasma free fatty acid concentrations inhibit insulin-stimulated glucose uptake in a dose-dependent manner in normal control subjects and in patients with NIDDM. Two possible mechanisms were identified: 1) a fat-related inhibition of glucose transport or phosphorylation that appeared after 3-4 h of fat infusion and 2) a decrease in muscle glycogen synthase activity that appeared after 4-6 h of fat infusion. We conclude that elevations of plasma FFAs caused insulin resistance and hence may play a significant role in the pathogenesis of insulin resistance in obesity and NIDDM.
Similar articles
-
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.Diabetes. 1997 Jan;46(1):3-10. Diabetes. 1997. PMID: 8971073 Review.
-
Intracellular defects in glucose metabolism in obese patients with NIDDM.Diabetes. 1992 Jun;41(6):698-706. doi: 10.2337/diab.41.6.698. Diabetes. 1992. PMID: 1587397
-
Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients.J Clin Invest. 1995 Dec;96(6):2639-45. doi: 10.1172/JCI118329. J Clin Invest. 1995. PMID: 8675629 Free PMC article.
-
The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus.J Clin Endocrinol Metab. 1991 Jan;72(1):96-107. doi: 10.1210/jcem-72-1-96. J Clin Endocrinol Metab. 1991. PMID: 1986032
-
Interaction between free fatty acids and glucose metabolism.Curr Opin Clin Nutr Metab Care. 2002 Sep;5(5):545-9. doi: 10.1097/00075197-200209000-00014. Curr Opin Clin Nutr Metab Care. 2002. PMID: 12172479 Review.
Cited by
-
Plasma metabolomic profiling of dietary patterns associated with glucose metabolism status: The Maastricht Study.BMC Med. 2022 Nov 21;20(1):450. doi: 10.1186/s12916-022-02653-1. BMC Med. 2022. PMID: 36414942 Free PMC article.
-
Differential subcutaneous adipose tissue gene expression patterns in a randomized clinical trial of efavirenz or lopinavir-ritonavir in antiretroviral-naive patients.Antimicrob Agents Chemother. 2014 Nov;58(11):6717-23. doi: 10.1128/AAC.03481-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155608 Free PMC article. Clinical Trial.
-
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4481-6. doi: 10.1073/pnas.0511246103. Epub 2006 Mar 14. Proc Natl Acad Sci U S A. 2006. PMID: 16537411 Free PMC article.
-
Pathophysiology of dyslipidaemia in the metabolic syndrome.Postgrad Med J. 2005 Jun;81(956):358-66. doi: 10.1136/pgmj.2004.025601. Postgrad Med J. 2005. PMID: 15937200 Free PMC article. Review.
-
Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis.Rheumatol Int. 2011 Apr;31(4):485-91. doi: 10.1007/s00296-009-1304-x. Epub 2009 Dec 20. Rheumatol Int. 2011. PMID: 20091036
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
