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. 1996 Jun:77 ( Pt 6):1145-9.
doi: 10.1099/0022-1317-77-6-1145.

Coincidental expression of E5a and c-jun in human papillomavirus type 6/11-infected condylomata

S L Chen  1 , T B Hsieh, Y P Tsao, C P Han, Y F Yang
Affiliations

Coincidental expression of E5a and c-jun in human papillomavirus type 6/11-infected condylomata

S L Chen et al. J Gen Virol. 1996 Jun.

Abstract

Previously, we have shown that E5a can induce expression of the c-jun gene in human papillomavirus (HPV)-11 E5a transformed NIH 3T3 cells and human epidermal keratinocytes. In this study, we investigated the relationship between expression of the E5a gene and c-jun in pathologically confirmed condylomata specimens using mRNA hybridization in situ. The c-jun RNA concentration was significantly higher in condylomata specimens with E5a mRNA expression than in specimens without E5a mRNA expression, or in normal cervical specimens. The cells with c-jun expression were located predominantly in the basal and parabasal cell layers. These layers were also the primary location of E5a-expressing cells. This is the first demonstration of a strong correlation (74%) between expression of the E5a and c-jun genes in condylomata specimens. This correlation might reflect regulation by HPV-11 E5a of c-jun gene expression in condyloma.

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