Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Apr 1;315 ( Pt 1)(Pt 1):21-4.
doi: 10.1042/bj3150021.

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

E A Slee  1 , H Zhu, S C Chow, M MacFarlane, D W Nicholson, G M Cohen
Affiliations

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

E A Slee et al. Biochem J. .

Abstract

Interleukin-1 beta converting enzyme (ICE)-like proteases, which are synthesized as inactive precursors, play a key role in the induction of apoptosis. We now demonstrate that benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK), an ICE-like protease inhibitor, inhibits apoptosis by preventing the processing of CPP32 to its active form. These results suggest that novel inhibitors of apoptosis can be developed which prevent processing of proforms of ICE-like proteases.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cancer Res. 1993 Sep 1;53(17):3976-85 - PubMed
    1. J Biol Chem. 1993 Feb 15;268(5):3037-9 - PubMed
    1. EMBO J. 1993 Sep;12(9):3679-84 - PubMed
    1. Cell. 1994 Sep 9;78(5):739-50 - PubMed
    1. Nature. 1994 Sep 22;371(6495):346-7 - PubMed

Publication types

MeSH terms

Substances