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. 1996 Apr;74(4):288-92.
doi: 10.1136/adc.74.4.288.

Cerebrospinal fluid soluble L-selectin (sCD62L) in meningoencephalitis

C Bührer  1 , R Herold, D Stibenz, G Henze, M Obladen
Affiliations

Cerebrospinal fluid soluble L-selectin (sCD62L) in meningoencephalitis

C Bührer et al. Arch Dis Child. 1996 Apr.

Abstract

The leucocyte adhesion molecule L-selectin (CD62L) is rapidly cleaved off proteolytically after cell activation, generating soluble L-selectin (sCD62L) molecules. sCD62L concentrations were determined in 185 cerebrospinal fluid (CSF) samples obtained from children aged 1 month to 17 years. In 36 CSF samples of children with meningoencephalitis, sCD62L was significantly higher (median 209 fmol/ml) than in samples of children with other febrile diseases (n = 67, median 50 fmol/ml) or non-febrile disorders (n = 82, median 44 fmol/ml). There was a positive correlation between CSF protein and CSF sCD62L (rS = 0.68), suggesting that a disturbed blood-brain barrier contributes to raised sCD62L concentrations in the CSF. However, the CSF sCD62L/protein ratio of children with meningoencephalitis was significantly higher than in children with other febrile diseases or non-febrile disorders, indicating that sCD62L concentrations in children with meningoencephalitis were higher than expected from plasma leakage alone. It is concluded that both an impaired blood-brain barrier and the generation of sCD62L by infiltrating leucocytes contribute to raised CSF sCD62L concentrations in children with meningoencephalitis.

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References

    1. Radiology. 1982 Apr;143(1):29-36 - PubMed
    1. Pediatr Res. 1995 Sep;38(3):336-41 - PubMed
    1. J Histochem Cytochem. 1986 Jul;34(7):949-52 - PubMed
    1. Science. 1989 Sep 15;245(4923):1238-41 - PubMed
    1. J Exp Med. 1989 Dec 1;170(6):1859-67 - PubMed

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