Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
- PMID: 8633247
- DOI: 10.1126/science.272.5267.1502
Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
Abstract
Women are particularly susceptible to malaria during first and second pregnancies, even though they may have developed immunity over years of residence in endemic areas. Plasmodium falciparum-infected red blood cells (IRBCs) were obtained from human placentas. These IRBCs bound to purified chondroitin sulfate A (CSA) but not to other extracellular matrix proteins or to other known IRBC receptors. IRBCs from nonpregnant donors did not bind to CSA. Placental IRBCs adhered to sections of fresh-frozen human placenta with an anatomic distribution similar to that of naturally infected placentas, and this adhesion was competitively inhibited by purified CSA. Thus, adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria.
Comment in
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Malaria hideout found in new mothers.Science. 1996 Jun 7;272(5267):1416-7. doi: 10.1126/science.272.5267.1416. Science. 1996. PMID: 8633226 No abstract available.
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