doi: 10.1016/s0092-8674(00)81031-4.
Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice
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- PMID: 8598042
- DOI: 10.1016/s0092-8674(00)81031-4
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Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice
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Abstract
CD30 is found on Reed-Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein-Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into alpha beta TCR-or gamma delta TCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion.
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