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. 1995 Jun;28(1):12-8.
doi: 10.1007/BF00311876.

Mating-type suppression of the DNA-repair defect of the yeast rad6 delta mutation requires the activity of genes in the RAD52 epistasis group

Y X Yan  1 , R H Schiestl, L Prakash
Affiliations

Mating-type suppression of the DNA-repair defect of the yeast rad6 delta mutation requires the activity of genes in the RAD52 epistasis group

Y X Yan et al. Curr Genet. 1995 Jun.

Abstract

The RAD6 gene of Saccharomyces cerevisiae is required for post-replication repair of UV-damaged DNA, UV mutagenesis, and sporulation. Here, we show that the radiation sensitivity of a MATa rad6 delta strain can be suppressed by the MAT alpha 2 gene carried on a multicopy plasmid. The a1-alpha 2 suppression is specific to the RAD6 pathway, as mutations in genes required for nucleotide excision repair or for recombinational repair do not show such mating-type suppression. The a1-alpha 2 suppression of the rad6 delta mutation requires the activity of the RAD52 group of genes, suggesting that suppression occurs by channelling of post-replication gaps present in the rad6 delta mutant into the RAD52 recombinational repair pathway. The a1-alpha 2 repressor could mediate this suppression via an enhancement in the expression, or the activity, of recombination genes.

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References

    1. Cell. 1981 Nov;27(1 Pt 2):15-23 - PubMed
    1. Mutat Res. 1994 Nov;315(3):281-93 - PubMed
    1. Mol Cell Biol. 1987 Mar;7(3):1012-20 - PubMed
    1. EMBO J. 1991 Aug;10 (8):2187-93 - PubMed
    1. Annu Rev Genet. 1993;27:33-70 - PubMed

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