Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1995;14(2):77-97.
doi: 10.1007/BF02918170.

Selective mechanisms utilized by persistent and oncogenic viruses to interfere with antigen processing and presentation

R Ehrlich  1
Affiliations
Review

Selective mechanisms utilized by persistent and oncogenic viruses to interfere with antigen processing and presentation

R Ehrlich. Immunol Res. 1995.

Abstract

Cell-mediated immunity is effective against cells harboring active virus replication, and is critical for the elimination of ongoing infections, regression of virus-associated tumors, and reducing or preventing the reactivation of persistent viruses. The capacity of persistent and oncogenic viruses to maintain a long-term relationship with their host presupposes viral mechanisms for circumventing antiviral defenses. By suppressing the expression of molecules associated with antigen processing and presentation, viruses abrogate the major immune mechanism that deals with the elimination of infected and tumor cells. This is accomplished either by transcriptional downregulation of genes encoding class I MHC antigens, peptide transporter molecules, and the proteasome-associated LMP subunits, or by interfering with transport of class I molecules to the cell surface. In some cases viruses shut off the expression of most viral proteins during latency or express mainly nonimmunogenic or antagonistic peptide epitopes. This review describes selective mechanisms utilized by viruses for interference with antigen processing and presentation, and addresses their significance for in vivo viral persistence and tumor progression.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Cancer Res. 1992 Jul 15;52(14):4009-16 - PubMed
    1. Nature. 1987 Jul 23-29;328(6128):345-8 - PubMed
    1. EMBO J. 1986 Oct;5(10):2599-607 - PubMed
    1. J Exp Med. 1982 Jul 1;156(1):79-89 - PubMed
    1. J Virol. 1991 Apr;65(4):1836-42 - PubMed

MeSH terms

Substances

LinkOut - more resources