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. 1993;52(25):2055-61.
doi: 10.1016/0024-3205(93)90690-5.

Influence of non-L-type calcium channel antagonists on phencyclidine-induced effects in rats

P Popoli  1 , A Pèzzola, A Scotti de Carolis
Affiliations

Influence of non-L-type calcium channel antagonists on phencyclidine-induced effects in rats

P Popoli et al. Life Sci. 1993.

Abstract

Omega-conotoxin (1 and 2 micrograms/10 microliter i.c.v.), a N-type calcium channel blocker, and amiloride (7.5 and 15 micrograms/10 microliter i.c.v.), a T-type calcium antagonist, significantly prevented the EEG and behavioural effects induced by phencyclidine (PCP, 5 mg/kg i.p.) in rats. In accordance with previous studies showing the significant influence of L-type calcium blockers in the same model, these results confirm that the modulation of calcium currents plays a key role in the expression of PCP-induced effects.

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