Factors involved in the regulation of mesangial cell proliferation in vitro and in vivo
- PMID: 8468926
Factors involved in the regulation of mesangial cell proliferation in vitro and in vivo
Abstract
One of the central features of many human glomerular diseases is the proliferation of the smooth muscle cell-like mesangial cells. While a multitude of mitogens for mesangial cells has been proposed on the basis of in vitro experiments, the factors involved in the regulation of mesangial cell proliferation in vivo remain largely undefined. To investigate the regulation of mesangial cell proliferation in vivo we have studied the mesangioproliferative glomerulonephritis that is induced by injection of antibody directed against the Thy 1.1 antigen on the mesangial cell surface in rats. In this review, we discuss the role of three cytokines in the mesangioproliferative response, namely platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), and transforming growth factor-beta (TGF-beta). All three cytokines are present in various inflammatory cells as well as in mesangial cells themselves, thereby allowing these factors to exert both paracrine and autocrine regulatory functions on mesangial cells. In vivo studies show that PDGF, bFGF and TGF-beta participate in either the mesangial cell proliferation or the mesangial matrix expansion that follows mesangial cell injury with anti-Thy 1.1 antibody. Based on currently available data we propose that bFGF may participate in the initiation, PDGF in the maintenance, and TGF-beta in the resolution of mesangial cell proliferation in vivo. Further analysis of the mitogens operative in vivo may ultimately result in the design of new therapeutic strategies to treat progressive glomerular mesangioproliferative diseases.
Similar articles
-
Mesangial cells in the pathogenesis of progressive glomerular disease in animal models.Clin Investig. 1992 Sep;70(9):857-64. doi: 10.1007/BF00180756. Clin Investig. 1992. PMID: 1450640 Review.
-
Cytokine regulation of mesothelial cell proliferation in vitro and in vivo.Eur J Cell Biol. 1997 Jan;72(1):24-9. Eur J Cell Biol. 1997. PMID: 9013722
-
Role of interleukin-1 in mesangial cell proliferation and matrix deposition in experimental mesangioproliferative nephritis.Am J Pathol. 1997 Jul;151(1):141-50. Am J Pathol. 1997. PMID: 9212740 Free PMC article.
-
Cytokines and mesangial cells.Kidney Int Suppl. 1993 Jan;39:S26-31. Kidney Int Suppl. 1993. PMID: 8468921 Review.
-
Autocrine growth regulation of human glomerular mesangial cells is primarily mediated by basic fibroblast growth factor.Am J Pathol. 1995 Nov;147(5):1372-82. Am J Pathol. 1995. PMID: 7485400 Free PMC article.
Cited by
-
Distinctive roles of neutrophils and monocytes in anti-thy-1 nephritis.Am J Pathol. 2000 Jan;156(1):303-10. doi: 10.1016/S0002-9440(10)64731-1. Am J Pathol. 2000. PMID: 10623679 Free PMC article.
-
Regulation of rat mesangial cell growth by diadenosine phosphates.J Clin Invest. 1995 Jun;95(6):2862-7. doi: 10.1172/JCI117992. J Clin Invest. 1995. PMID: 7769127 Free PMC article.
-
High glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells.Am J Pathol. 1996 Dec;149(6):2095-106. Am J Pathol. 1996. PMID: 8952542 Free PMC article.
-
The profile of gene expression and role of nuclear factor kappa B on glomerular injury in rats with Thy-1 nephritis.Clin Exp Immunol. 2008 Jun;152(3):559-67. doi: 10.1111/j.1365-2249.2008.03654.x. Epub 2008 Apr 16. Clin Exp Immunol. 2008. PMID: 18422731 Free PMC article.
-
Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells.J Clin Invest. 1995 Jul;96(1):401-10. doi: 10.1172/JCI118049. J Clin Invest. 1995. PMID: 7615811 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Other Literature Sources