doi: 10.1038/365721a0.
Direct observation of kinesin stepping by optical trapping interferometry
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- PMID: 8413650
- DOI: 10.1038/365721a0
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Direct observation of kinesin stepping by optical trapping interferometry
Nature.
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Abstract
Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed their motion under controlled loads by interferometry. We find that kinesin moves with 8-nm steps.
Comment in
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Molecular motors. One giant step for kinesin.Nature. 1993 Oct 21;365(6448):696-7. doi: 10.1038/365696b0. Nature. 1993. PMID: 8413646 No abstract available.
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