LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor
- PMID: 8390097
- DOI: 10.1126/science.8390097
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor
Abstract
The ciliary neurotrophic factor (CNTF) receptor complex is shown here to include the CNTF binding protein (CNTFR alpha) as well as the components of the leukemia inhibitory factor (LIF) receptor, LIFR beta (the LIF binding protein) and gp130 [the signal transducer of interleukin-6 (IL-6)]. Thus, the conversion of a bipartite LIF receptor into a tripartite CNTF receptor apparently occurs by the addition of the specificity-conferring element CNTFR alpha. Both CNTF and LIF trigger the association of initially separate receptor components, which in turn results in tyrosine phosphorylation of receptor subunits. Unlike the IL-6 receptor complex in which homodimerization of gp130 appears to be critical for signal initiation, signaling by the CNTF and LIF receptor complexes depends on the heterodimerization of gp130 with LIFR beta. Ligand-induced dimerization of signal-transducing receptor components, also seen with receptor tyrosine kinases, may provide a general mechanism for the transmission of a signal across the cell membrane.
Similar articles
-
Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor.J Biol Chem. 1997 Sep 12;272(37):23069-75. doi: 10.1074/jbc.272.37.23069. J Biol Chem. 1997. PMID: 9287306
-
Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component.J Biol Chem. 1993 Apr 15;268(11):7628-31. J Biol Chem. 1993. PMID: 8385113
-
Expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFR alpha, LIFR beta, IL-6R alpha, and gp130) in human peripheral neuropathies.Neurochem Res. 2001 Jan;26(1):51-8. doi: 10.1023/a:1007628631985. Neurochem Res. 2001. PMID: 11358282
-
The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines.J Neurobiol. 1994 Nov;25(11):1454-66. doi: 10.1002/neu.480251111. J Neurobiol. 1994. PMID: 7852997 Review.
-
The ciliary neurotrophic factor and its receptor, CNTFR alpha.Pharm Acta Helv. 2000 Mar;74(2-3):265-72. doi: 10.1016/s0031-6865(99)00050-3. Pharm Acta Helv. 2000. PMID: 10812968 Review.
Cited by
-
Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa.Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1389-400. doi: 10.1167/iovs.06-0677. Invest Ophthalmol Vis Sci. 2007. PMID: 17325188 Free PMC article.
-
Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration.J Neurosci. 2002 Nov 1;22(21):9228-36. doi: 10.1523/JNEUROSCI.22-21-09228.2002. J Neurosci. 2002. PMID: 12417648 Free PMC article.
-
Humanin and the receptors for humanin.Mol Neurobiol. 2010 Feb;41(1):22-8. doi: 10.1007/s12035-009-8090-z. Epub 2009 Dec 9. Mol Neurobiol. 2010. PMID: 19997871 Review.
-
JAK-STAT3 and somatic cell reprogramming.JAKSTAT. 2013 Oct 1;2(4):e24935. doi: 10.4161/jkst.24935. Epub 2013 May 7. JAKSTAT. 2013. PMID: 24470976 Free PMC article. Review.
-
Neuronal activity and axonal sprouting differentially regulate CNTF and CNTF receptor complex in the rat supraoptic nucleus.Exp Neurol. 2012 Jan;233(1):243-52. doi: 10.1016/j.expneurol.2011.10.009. Epub 2011 Oct 19. Exp Neurol. 2012. PMID: 22037350 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
