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Comparative Study
. 1993:78:93-9; discussion 99-100.

Significance of a newly identified attenuating mutation in Sabin 3 oral poliovirus vaccine

S J Mento  1 , C Weeks-Levy, J M Tatem, E J Gorgacz, W F Waterfield
Affiliations
  • PMID: 8388835
Comparative Study

Significance of a newly identified attenuating mutation in Sabin 3 oral poliovirus vaccine

S J Mento et al. Dev Biol Stand. 1993.

Abstract

Sequence analysis of poliovirus vaccine RNA has resulted in the identification of a new point mutation at position 2493 in Sabin 3. cDNA-derived Sabin 3 virus whose genome includes the new mutation has phenotypic properties expected for a vaccine strain. Virus engineered to contain a single base substitution at 2493 has lost the small plaque phenotype, and low neurovirulence characteristics normally associated with Sabin poliovirus strains. The significance of these observations and a potential relationship to the frequency of vaccine-associated poliomyelitis are described.

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