Review
Attenuation and reversion of the Sabin vaccine strains of poliovirus
Affiliations
- PMID: 8388828
Item in Clipboard
Review
Attenuation and reversion of the Sabin vaccine strains of poliovirus
Dev Biol Stand.
1993.
Abstract
Studies of the molecular basis of the attenuation and reversion of the attenuated phenotype of the Sabin vaccine strains suggest that few mutations are involved. It is striking that mutations in the 5' non-coding region within a 10 base region implicated in a base pair structure have been identified in all the Sabin vaccine strains. The mutations have effects on in vitro phenotypes which have implications for the production of vaccines.
Similar articles
-
Genetic basis of attenuation of the Sabin oral poliovirus vaccines.Biologicals. 1993 Dec;21(4):357-63. doi: 10.1006/biol.1993.1096. Biologicals. 1993. PMID: 8024751 Review. No abstract available.
-
Approaches to the construction of new candidate poliovirus type 3 vaccine strains.Dev Biol Stand. 1993;78:161-9; discussion 169-70. Dev Biol Stand. 1993. PMID: 8388827 Review.
-
Significance of a newly identified attenuating mutation in Sabin 3 oral poliovirus vaccine.Dev Biol Stand. 1993;78:93-9; discussion 99-100. Dev Biol Stand. 1993. PMID: 8388835
-
Genomic modifications in naturally occurring neurovirulent revertants of Sabin 1 polioviruses.Dev Biol Stand. 1993;78:33-8. Dev Biol Stand. 1993. PMID: 8099049
-
Development of candidates for new type 2 and type 3 oral poliovirus vaccines.Dev Biol Stand. 1993;78:141-8. Dev Biol Stand. 1993. PMID: 8388824
Cited by
-
Synonymous genome recoding: a tool to explore microbial biology and new therapeutic strategies.Nucleic Acids Res. 2019 Nov 18;47(20):10506-10519. doi: 10.1093/nar/gkz831. Nucleic Acids Res. 2019. PMID: 31584076 Free PMC article. Review.
-
An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses.Sci Rep. 2015 Nov 25;5:17291. doi: 10.1038/srep17291. Sci Rep. 2015. PMID: 26603565 Free PMC article.
-
Experimental evolution alters the rate and temporal pattern of population growth in Batrachochytrium dendrobatidis, a lethal fungal pathogen of amphibians.Ecol Evol. 2014 Sep;4(18):3633-41. doi: 10.1002/ece3.1199. Epub 2014 Sep 3. Ecol Evol. 2014. PMID: 25478154 Free PMC article.
-
A live-attenuated HSV-2 ICP0 virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccine.PLoS One. 2011 Mar 11;6(3):e17748. doi: 10.1371/journal.pone.0017748. PLoS One. 2011. PMID: 21412438 Free PMC article.
-
Natural type 3/type 2 intertypic vaccine-related poliovirus recombinants with the first crossover sites within the VP1 capsid coding region.PLoS One. 2010 Dec 21;5(12):e15300. doi: 10.1371/journal.pone.0015300. PLoS One. 2010. PMID: 21203565 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources