doi: 10.1128/JVI.67.6.3671-3673.1993.
Simian virus 40 small-t antigen binds two zinc ions
Affiliations
- PMID: 8388518
- PMCID: PMC237723
- DOI: 10.1128/JVI.67.6.3671-3673.1993
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Simian virus 40 small-t antigen binds two zinc ions
J Virol.
1993 Jun.
Abstract
Six cysteine residues of the simian virus 40 small-t antigen (small-t) are important for stability of the protein. Stability has been shown to be related to the ability of small-t to bind zinc ions in vitro. Purified small-t expressed either in bacteria or from baculovirus vectors binds two molecules of zinc per molecule of protein. Thus, small-t may resemble GAL4, which contains a Zn(II)2Cys6 binuclear cluster.
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