doi: 10.1016/0092-8674(93)90421-l.
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine
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- PMID: 8343957
- DOI: 10.1016/0092-8674(93)90421-l
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Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine
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Abstract
The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.
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