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Comparative Study
. 1993;55(4):731-43.
doi: 10.1007/BF02460671.

Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal

C Donnelly  1 , W Leisenring, P Kanki, T Awerbuch, S Sandberg
Affiliations
Comparative Study

Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal

C Donnelly et al. Bull Math Biol. 1993.

Abstract

To explore the biological similarities and differences between the HIV-1 and HIV-2 viruses, we model the probability of male-to-female transmission of either HIV virus as a function of the number of sexual partners, the prevalence of the viruses and the infectivity per contact. Using maximum likelihood estimation theory and data from a prospective study of registered female prostitutes in Dakar, Senegal, we estimate and compare the infectivities of HIV-1 and HIV-2. Graphical goodness-of-fit methods are used to show that our model fits the data well. We find that in male-to-female transmission HIV-1 is significantly more infectious than HIV-2. This finding is consistent with other data from laboratory and epidemiologic studies comparing the biology of HIV-1 and HIV-2.

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