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. 1993 Dec 10;262(5140):1741-4.
doi: 10.1126/science.8259520.

Elements of the yeast pheromone response pathway required for filamentous growth of diploids

H Liu  1 , C A Styles, G R Fink
Affiliations

Elements of the yeast pheromone response pathway required for filamentous growth of diploids

H Liu et al. Science. .

Abstract

Transmission of an external signal from receptors to downstream targets is often mediated by a conserved set of protein kinases that act in sequence (a kinase cascade). In haploid strains of Saccharomyces cerevisiae, a signal initiated by peptide pheromones is transmitted through this kinase cascade to a transcription factor STE12, which is required for the expression of many mating-specific genes. Here it was shown that in diploids some of the same kinases and STE12 are required for filamentous growth, but the pheromone receptors and guanosine triphosphate-binding protein are not required for filament formation. Thus, a similar kinase cascade is activated by different signals in haploids and diploids and mediates different developmental outcomes in the two cell types.

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