Molecular biology and evolution of filoviruses
- PMID: 8219816
- DOI: 10.1007/978-3-7091-9300-6_8
Molecular biology and evolution of filoviruses
Abstract
The family Filoviridae contains extremely pathogenic human viruses causing a fulminating, febrile hemorrhagic disease. Filoviruses are enveloped, filamentous particles with a nonsegmented negative-strand RNA genome showing the gene arrangement 3'-NP-VP35-VP40-GP-VP30-VP24-L-5'. Genes are flanked by highly conserved transcriptional signals and are generally separated by variable intergenic regions. They are transcribed into monocistronic polyadenylated messenger RNAs which contain relatively long 5' and 3' untranslated regions. Seven structural proteins are encoded by the genome of which four form the helical nucleocapsid (NP-VP35-VP30-L), two are membrane-associated (VP40-VP24), and one is a transmembrane glycoprotein (GP). Comparison of filovirus genomes with those of other nonsegmented negative-strand RNA viruses suggest comparable mechanisms of transcription and replication and a common evolutionary lineage for all these viruses. Sequence analyses of single genes, however, showed that filoviruses are more closely related to paramyxoviruses, particularly human respiratory syncytial virus. These data support the concept of the taxonomic order Mononegavirales for all nonsegmented negative-strand RNA viruses and the classification of Marburg virus, Ebola virus, and Reston virus in the family Filoviridae, separate from the families Paramyxoviridae and Rhabdoviridae.
Similar articles
-
Marburg virus, a filovirus: messenger RNAs, gene order, and regulatory elements of the replication cycle.Virus Res. 1992 Jun;24(1):1-19. doi: 10.1016/0168-1702(92)90027-7. Virus Res. 1992. PMID: 1626422
-
Filovirus helical nucleocapsid structures.Microscopy (Oxf). 2023 Jun 8;72(3):178-190. doi: 10.1093/jmicro/dfac049. Microscopy (Oxf). 2023. PMID: 36242583 Review.
-
Filoviruses: Ecology, Molecular Biology, and Evolution.Adv Virus Res. 2018;100:189-221. doi: 10.1016/bs.aivir.2017.12.002. Epub 2018 Feb 1. Adv Virus Res. 2018. PMID: 29551136 Free PMC article. Review.
-
Sequence analysis of the Ebola virus genome: organization, genetic elements, and comparison with the genome of Marburg virus.Virus Res. 1993 Sep;29(3):215-40. doi: 10.1016/0168-1702(93)90063-s. Virus Res. 1993. PMID: 8237108
-
VP24 of Marburg virus influences formation of infectious particles.J Virol. 2005 Nov;79(21):13421-33. doi: 10.1128/JVI.79.21.13421-13433.2005. J Virol. 2005. PMID: 16227263 Free PMC article.
Cited by
-
A seroepidemiologic study of Reston ebolavirus in swine in the Philippines.BMC Vet Res. 2012 Jun 18;8:82. doi: 10.1186/1746-6148-8-82. BMC Vet Res. 2012. PMID: 22709971 Free PMC article.
-
A system for functional analysis of Ebola virus glycoprotein.Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14764-9. doi: 10.1073/pnas.94.26.14764. Proc Natl Acad Sci U S A. 1997. PMID: 9405687 Free PMC article.
-
Characterization of a putative filovirus vaccine: virus-like particles.Virol Sin. 2013 Apr;28(2):65-70. doi: 10.1007/s12250-013-3306-9. Epub 2013 Feb 6. Virol Sin. 2013. PMID: 23385315 Free PMC article. Review.
-
Structural and Functional Aspects of Ebola Virus Proteins.Pathogens. 2021 Oct 15;10(10):1330. doi: 10.3390/pathogens10101330. Pathogens. 2021. PMID: 34684279 Free PMC article. Review.
-
Ebola Virus Infection: Overview and Update on Prevention and Treatment.Infect Dis Ther. 2015 Dec;4(4):365-90. doi: 10.1007/s40121-015-0079-5. Epub 2015 Sep 12. Infect Dis Ther. 2015. PMID: 26363787 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Miscellaneous