Review
doi: 10.1016/0959-437x(94)90098-1.
Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death
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- PMID: 8193530
- DOI: 10.1016/0959-437x(94)90098-1
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Review
Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death
Curr Opin Genet Dev.
1994 Feb.
Abstract
The Myc oncoprotein dimerizes with its partner, Max, to bind DNA, activate transcription, and promote cell proliferation, as well as programmed cell death. Max also forms homodimers or heterodimers with its alternative partners, Mad and Mxi-1. These complexes behave as antagonists of Myc/Max through competition for common DNA targets, and perhaps permit cellular differentiation.
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