Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 May;93(5):2206-14.
doi: 10.1172/JCI117217.

p53 expression during normal tissue regeneration in response to acute cutaneous injury in swine

H N Antoniades  1 , T Galanopoulos, J Neville-Golden, C P Kiritsy, S E Lynch
Affiliations
Comparative Study

p53 expression during normal tissue regeneration in response to acute cutaneous injury in swine

H N Antoniades et al. J Clin Invest. 1994 May.

Abstract

The present studies investigated the in vivo expression of the p53 suppressor gene and protein product in response to acute cutaneous injury in swine, along with the parallel expression of the c-sis/PDGF-B mitogen and its receptor beta (PDGF-R beta). p53 expression was shown to be suppressed during the period of active cellular proliferation in the injured tissue and to reemerge during the stages of healing. In contrast, c-sis/PDGF-B and PDGF-R beta were expressed during the early phase of active cellular proliferation and they were suppressed upon healing. This inverse relationship between mitogenic growth factors and p53 suggests the presence of well-controlled physiologic mechanisms that regulate in vivo the processes of normal tissue repair in response to injury. At the stages of tissue regeneration, these mechanisms include both the expression of growth factors that promote cell proliferation and the suppression of p53 that downregulates proliferation. At the stages of healing, the expression of the mitogenic growth factors is suppressed and that of p53 reemerges, reaching its peak at the time of complete epithelialization and healing of the injured tissue. These studies are the first to link the response of p53 protein to physiologic processes of tissue regeneration in vivo.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cell. 1989 Jun 30;57(7):1083-93 - PubMed
    1. Cancer Res. 1991 Dec 1;51(23 Pt 1):6304-11 - PubMed
    1. J Clin Invest. 1989 Aug;84(2):640-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):9979-83 - PubMed
    1. Baillieres Clin Endocrinol Metab. 1991 Dec;5(4):595-613 - PubMed

Publication types

MeSH terms

Substances